Hello dwc,
The first thing that comes to mind, is the ftd2xx.dll file present in the same folder as your executable?
Windows 10 shouldn’t make a difference.
You could try to run your application out of the Spike directory. You could use dependency walker to determine if you are missing any dependencies.
Are you using Visual Studio to develop your application? Are you able to run your application from within Visual Studio on the Windows 10 machine?
Let me know if none of these work.
Regards,
Andrew
